Influenza can hide from the immune system

Wednesday, Feb 24, 2016,14:41 IST By Metrovaartha A A A

London | Influenza virus is able to mask itself so that it is not initially detected by our immune system, according to a new study that may help develop better treatments for flu and other chronic inflammation conditions. Previously, researchers had found that the immune system can already track viruses and alert the body as soon as a virus enters human cells to multiply. But the new study shows that the influenza virus cheats the mechanism and is thus able to circumvent the body’s advanced defence system.

The virus contains a protein that masks the virus entering the cell. In this way, the influenza virus can spread more easily before the immune system recognises that it is a virus and attempts to fight it, said Associate Professor Christian Holm from the Aarhus University in Denmark. The influenza virus has developed this weapon against the immune system through evolution.

The researchers discovered the mechanism by giving cells in the laboratory an evolutionarily conserved influenza virus protein. The result was that the cells became poorer at defending themselves against both influenza viruses and other types of viruses. This indicates that the recognition mechanism in the immune system that the influenza virus evades is generally important for the body’s ability to defend itself against viruses. It is therefore important basic research knowledge for us.

The more knowledge we have about why a virus becomes dangerous, the easier it is to develop treatments, said Holm. The little protein that is able to mask the influenza virus from the immune system is not only interesting in relation to combating influenza. It may be possible to use it to combat autoimmune diseases such as rheumatoid arthritis, as well as the relatively rare disease lupus, which to a great extent affects young women. In these diseases, the immune system attacks healthy cells and tissues – though the reasons for this are unknown – and creates chronic inflammation.

The protein’s immunosuppressant effect can possibly be used to develop better treatments for these types of diseases, where the immune system is chronically overactive. By suppressing the immune system’s reaction, the symptoms can be reduced. The results of our research can also be used to examine this in more detail, Holm added.

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