Washington | Researchers, including one of Indian-origin, have created a new therapeutic for prostate cancer that has shown great efficacy in mouse models of the disease.
The treatment is designed to inhibit the activity of a protein called PAK-1, which contributes to the development of highly invasive prostate cancer cells, researchers said. Prostate cancer is one of the leading causes of cancer death among men of all races. PAK-1 is kind of like an on/off switch. When it turns on, it makes cancerous cells turn into metastatic cells that spread throughout the body, said Somanath Shenoy from University of Georgia (UGA) in the US.
With the help of Brian Cummings from UGA, researchers developed a way to package and administer a small molecule called IPA-3, which limits the activity of PAK-1 proteins. They enveloped the IPA-3 molecule in a bubble-like structure called a liposome and injected it intravenously. The liposome shell surrounding IPA-3 ensures that it is not metabolised by the body too quickly, allowing the inhibitor enough time to disrupt the PAK-1 protein.
Researchers found that this molecule significantly slowed the progression of cancer in mice, and it also forced the cancerous cells to undergo apoptosis – a kind of programmed cell death. When we first began these experiments, we injected IPA-3 directly into the bloodstream, but it was absorbed so quickly that we had to administer the treatment seven days a week for it to be effective, said Shenoy.
But the liposome that Dr Cummings created makes the IPA-3 much more stable, and it reduced the treatment regimen to only twice a week, he said. The preliminary results suggest that IPA-3 might be a viable treatment for prostate cancer in humans, but Shenoy cautions that much work must be done before human clinical trials can begin.
The results of our experiments are promising, and we hope to move towards clinical trials soon but we must figure out what side effects this treatment may have before we can think about using it in humans, he said.