Novel method may help burn victims grow new skin: study

Sunday, Sep 25, 2016,15:58 IST By Metrovaartha A A A

New York  | Researchers have developed a novel method that measures the limit to which human skin can be stretched, an advance that could help grow new skin for burn victims.

“Surgeons use a variety of techniques to grow skin for tissue expansion procedures designed to grow skin in one region of the body so that it can be auto-grafted on to another site (sometimes used for burn victims),” said Guy German, assistant professor at Binghamton University in the US.

“This procedure stretches the skin, typically, by inflating a balloon with air or silicone under the surface,” said German.
“Skin grows more in regions where it is stretched – during pregnancy, for instance – but stretch it too much and the tissue might break,” German said.

The new predictive technique could be employed in this field as a method of predicting the limit to which the skin could be stretched.
The outermost layer of skin, the stratum corneum, regulates water loss from the body and protects underlying living tissue from germs and the environment, in general.
It is pretty tough, protecting the body from extreme temperatures, rough surfaces, and most paper edges.

“Most people think skin is smooth and flat just like a Photoshopped advertisement. It is not. If you look at the back of your hand, skin has small triangular patterns on it,” said German.
“These shapes are caused by small canyons in the skin.
Those canyons act just like notebook perforations when you tear a page out; they are weak points. We wanted to see how these topographical features acted as weak points of the skin,” said German.

Researchers, including those from State University of New York, assumed skin is smooth and without major cracks and looked how the toughness of skin varied significantly in relation to its water content. They found dry skin is brittle and easier to break than hydrated skin.
Researchers then used advanced imaging to track skin deformation and stretching which, combined with the structure of the skin itself, correlates to where cracks in skin begin.
This can help scientists and doctors predict where fractures may occur in the future.

Next, scientists found that cracks in the skin are not straight; instead they follow topographical ridges of skin, which have triangular patterns.
Researchers proved that most fractures propagate along cell-cell junctions rather than breaking the cells themselves.

This does not always happen, but it suggests that cell junctions are structurally the weakest points of the skin.

The results could help create new topical medical creams, soaps and cosmetic products. It may also be used in more extreme cases, researchers said.