Toronto | Vaccinating against dengue fever can increase Zika outbreaks, a new study by an international team of scientists has warned.
More than a third of the world’s population lives in areas where dengue is endemic and cases of co-infection with Zika have already been reported.
As dengue and Zika are both part of the Flaviviridae family transmitted through a common mosquito host, the researchers wanted to know how vaccinating for one would affect the incidence of the other.
“Vaccinating against one virus could not only affect the control of another virus, it could in fact make it easier for the other to spread,” said Jianhong Wu, professor at York University in Canada.
“Recent evidence suggests that dengue virus antibodies can enhance the Zika virus infection. For that reason, we developed a new math model to investigate the effect of dengue vaccination on Zika outbreaks,” said Wu.
The team’s model shows that vaccinations for dengue increase the number of people contracting Zika.
It also shows that the more people in a particular population that are vaccinated against dengue, the earlier and larger the Zika outbreak.
The research also found that the most effective way to minimise the unintended effect of dengue vaccinations on Zika outbreaks is through an integrated strategy that includes mosquito control.
“We concluded that vaccination against dengue among humans can significantly boost Zika transmission among the population and hence call for further study on integrated control measures on controlling dengue and Zika outbreak,” said Yanni Xiao, professor at Xi’an Jiaotong University in China.
The findings do not discourage the development and promotion of dengue vaccine products, however, more work needs to be done to understand how to optimise dengue vaccination programs and minimise the risk of Zika outbreaks.
According to the World Health Organisation (WHO), the global incidence of dengue has grown dramatically in recent decades, with about half of the world’s population now at risk.
In some Asian and Latin American countries, severe dengue is a leading cause of serious illness and death among children.
Whereas the outbreaks of Zika have occurred in Africa, the Americas, Asia and the Pacific, and has been linked to microcephaly and Guillain-Barre syndrome.
Although vaccines for dengue have been developed and are in use, there is no vaccine for Zika.
The study was published in the journal Scientific Reports.